Ghrelin stimulates proliferation and differentiation and inhibits
We identified mRNA and protein expression of GHS R in primary osteoblasts as well as a number of osteoblastic cell lines including MC3T3 E1 ROS 17/ UMR 106 MG63 and SaOS2 cells Treatment of ghrelin 10 11 to 10 7 M to MC3T3 E1 cells showed dose dependent stimulation of proliferation which was abrogated by treatment with [d Lys